乙肝清丸治疗慢性乙型肝炎肝纤维化的临床研究

Clinical Study on Anti Liver Fibrosis Effect of Yiganqing Pill in Patients with Chronic Hepatitis B.

研究乙肝清丸对慢性乙型肝炎肝纤维化的治疗作用及可能机理。190例慢乙肝患者随机分成2组,治疗组122例给予乙肝清丸,对照组68例给予复方丹参滴丸,均治疗6个月。观察治疗前后患者血清肝纤维化指标(HA、LN、ⅣC、PCⅢ)及肝脏病理学(HE染色)的变化。治疗后,显效率和总有效率治疗组分别为34.4%、70.5%,对照组分别为20.6%、51.5%,差异具有显著性(P<0.05或P<0.01)。治疗组肝纤维化指标均有所下降,尤其是HA、ⅣC及PCⅢ,与对照组比较有显著性差异(P<0.05或P<0.01)。治疗组12例肝活检证实,治疗后肝脏炎症减轻或消失,纤维组织增生减少。乙肝清丸有明显的抗肝纤维化作用。

To explore the clinical effect and possible mechanism of Yiganqing pill in antiliver fibrosis.190 patients with chronic hepatitis B were divided into 2 groups randomly.The 122 cases in the treated group were treated by Yiganqing pill and 68 patients in the control group were treated by Fufangdansendiwan for 6 months.Levels of serum hyaluronic acid(HA),laminin (LN),collagen type Ⅳ(ⅣC),procollagen Ⅲ (PCⅢ) and pathological changes of liver tissues were observed before and after treatment.After therapy,The total effective rate in the treated group was 70.5%,that in the control group was 51.5%,there was significant difference between the 2 groups (P<0.01). The levels of serum markers of liver fibrosis in the treated group declined apparently,especially in HA,ⅣC and PCⅢ,compared with the control group,there was significant difference (P<0.05 or P<0.01).Pathological examination of 12 cases in the treated group showed fibrosis tissue proliferation reduced significantly.Yiganqing pill has definite effect in anti liver fibrosis.