两种自家免疫性甲低患者治疗前后血清TSII、TGII及外周血T淋巴细胞亚群的变化

CHANGES OF SERUM TSII, TGII AND PERIPHERAL BLOOD T LYMPHOCYTES SUBSETS IN PATIENTS WITH TWO GROUPS OF AUTOIMMUNE HYPOTHYROIDISM BEFORE AND AFTER TREATMENT

对９例原发性粘液性水肿和１４例Ｈａｓｈｉｍｏｔｏ甲状腺炎患者测定了血清ＴＳＩＩ、ＴＧＩＩ及外周血Ｔ淋巴细胞亚群，并以３２例正常人作为对照．原发性粘液性水肿和Ｈａｓｈｉｍｏｔｏ甲状腺炎患者血清存在ＴＳＩＩ、ＴＧＩＩ，阳性比例不同，而且外周血ＣＤ８＋百分率降低和ＣＤ４＋／ＣＤ８＋比值增高．ＴＳＩＩ、ＴＧＩＩ活性与ＣＤ４＋／ＣＤ８＋比值无显著相关．经甲状腺激素治疗，两种自家免疫性甲低患者甲状腺功能明显恢复，血清ＴＳＩＩ、ＴＧＩＩ活性无明显变化，原发性粘液性水肿患者外周血Ｔ淋巴细胞亚群未见明显变化，而Ｈａｓｈｉｍｏｔｏ甲状腺炎患者ＣＤ８＋百分率明显回升．

Abstract Serum thyroid stimulation inhibiting immunoglobulin(TSII)and thyroid growth inhibiting immunoglobulin(TGII)were measured and pan T cells (CD3),helper/ inducer T cells (CD4) and suppressor/cytoxic T cells(CD8)in peripheral blood were enumerated in 9 patients with primary myxedema, 14 patients with Hashimoto'thyroiditis and 32 normal individuals. The results showed that TSII and TGII were present in sera of patients in this two groups of autoimmune hypothyroidism.With different positive rates the percentages of CD cell were decreased, whiles the CD CD ratio were increased.TSll and TGII activities were not correlated with the CD CD ratio. At the sixth week of treatment with thyroid tablets in 4 cases of 9 patients with primary myxedema and 7 cases of 14 patients with Hashimoto'thyroiditis,their thyroid function was recovered, but TSII and TGII activities were not significantly changed.Peripheral blood T lymphocyte subsets were not significantly varied in patients with primary myxedema, but the percentage of CD cells were significantly increased in patients with Hashimoto' thyroiditis. Pathogenic roles and clinical significance of serum TSII,TGIIand peripheral blood T lymphocyte subsets in these two groups of autoimmune hypothyroidism were also discussed.