摘要
采用T_(739)近交系小鼠进行实验,发现小鼠LA_(795)肺腺癌实体瘤中的瘤浸润淋巴细胞(TIL)体外经白细胞介素2(IL_2)激活,具有明显的抗肿瘤作用。体外杀瘤活性用氚-胸腺嘧啶核苷( ̄3H-TdR)释放法测定表明:TIL的杀瘤活性明显高于自然杀伤细胞(LAK)。体内的抗肿瘤作用主要观察TIL抑制自发性肺转移作用。实验1静脉注射或瘤周注射TIL的自发性肺转移抑制率分别为73.5%,79.9%;实验2的结果与实验1相似,且TIL治疗组的自发性肺转移抑制作用强于LAK细胞治疗组3倍。
umor InfiItrating Ly mphocytes(TILs)isolatedfrom LA_(795) lung adenocarcinoma in mice have a remarkable antitumor activity,by using T_(739) syngeneic mice.TILs cytolytic activity in vitro is higher than that ofLAK cells. TILs significantly inhibit spontaneous lungmetastasis in vivo. The results in experiment I showedthe following:TILs injection in tail vein,the inhibito-ry rate is 73.3%; TILs injection at tumor, 79.9%.The results in experiment II are similar to these in ex-periment I,and TILs antitumor activity in vivo is asthree times as that of LAK cells.
出处
《中华结核和呼吸杂志》
CAS
CSCD
北大核心
1994年第3期165-167,共3页
Chinese Journal of Tuberculosis and Respiratory Diseases
关键词
肺肿瘤
淋巴细胞
肿瘤转移
Lung neoplasms Lymphocytes,tu-mor infiltrating (TILs) Neoplasm metastasis