低剂量^(134)Cs内照射对中枢免疫器官免疫反应的兴奋效应研究

Stimulatory effect of low dose^(134)Cs on cells of central immunological organs

作者探讨了机体受低剂量裂变产物１３４Ｃｓ内照射时的体内滞留对中枢免疫器官骨髓和胸腺免疫细胞的刺激增生作用．１３４Ｃｓ的体内滞留过程包括快、慢两个不同的滞留半减期，其中快组份的Ｔ１＝０．０７天，慢组份的Ｔ２＝１６．３８天．实验结果表明：当机体摄入低剂量１３４Ｃｓ０．１８５和０．７４ｋＢｑ·ｇ－１时，即此时的全身累积吸收剂量为０．９１ｃＧｙ和４．５６ｃＧｙ作用下，发现骨髓细胞和胸腺细胞的３Ｈ－ＴｄＲ掺入率呈显著增升，表明其ＤＮＡ合成能力的增高，呈现出１３４Ｃｓ内照射对中枢免疫器官骨髓和胸腺免疫反应增强的兴奋效应．

The dynamic retention of fission product 134Cs and its stimulatory effect on cells of central immunological organs such as bone marrow cells and thymus cells were investigated. The whole body retention of 134Cs was well described by a two-exponential function, that is: R(t) =18.04e-9,817t+45. 13e-0.0423 t There are two retention components: the fast and the slow ones. The effective and biological T1/2 were 0. 07 and 16. 38 days, respectively. Results show that the proliferative capacity of bone marrow cells and thymus cells were excited with a low dose irradiation of 134Cs from 0.185 to 0.74 kBq/g while the cumulative absorbed dose of 134Cs was 0.91 and 4.56 cGy.It should be noted that under this condition the phenomenon of stimulatory response of cell potentiation induced by an exposure to a low dose 134Cshas been observed.