氚在孕鼠体内的分布和向胎鼠转移特点的研究

Metabolism and transfer pattern of tritium in mice after single injection of tritiated water

作者重点研究了氚水在孕鼠和胎体内的分布代谢及母体中的氚通过不同转移方式向仔代转移的特点．实验用Ｃ５７ＢＬ纯种小鼠，１次腹腔注入１．８５×１０４Ｂｑ／ｇ体重的氚水。实验结果表明；氚能通过胎盘向胎鼠转移，在氚注入后的第２天母体中所测组织器官中的氚活度占注入量的５１％，到第２０天时为１％～２％．各组织间的氚分布水平相差不大，转移系数为０．９９．母体氚也能通过乳汁向胎鼠转移，表现于氚在母体组织中的活度分布低于氚在仔鼠相同组织中的活度．使氚自母体向仔鼠的转移系数超过１～２．可认为，母体氚通过乳汁向仔鼠的转移比通过胎盘转移的转移系数大，因此其辐射影响更大．

Metabolism and transfer pattern oftritium from pregttant mice into fetusesafter intra peritoneal injection of tritiatedwater ovas investigated. The pregnantmice were divided into three experimental groups: group 1 was injected withtritiated water on the first day ofgestation to obtain the transfer coefficient of tritium from pregnant mice intofoetuses through placenta; group 2 wasinjected with tritiated water on the firstday of parturition to study the transfercoefficient of tritium from pregnant miceinto their babies through milk : group 3 wasinjected with tritiated water in differentperiods of gestation. The results showthat in group 1, tritiated water wasalmost uniformly distributed in thewhole body, including placenta, foetalmembrane and amniotic fluid: placenta didnot affect tritium transfer from pregnantmouce into foetus. In groups 2 and 3,concentrations of tritium in the baby'stissues were evidently higher than thosein the pregnant mouse, and the transfercoefficients in groups 2 and 3 werehigher than that in group 1.