低剂量^(60)Coγ射线宫内一次照射对仔鼠生后生长发育及行为的影响

Effects of low-level prenatal γ-ray irradiation on postnatal growth and behavior in mice

作者报道了成年Ｃ５７ＢＬ／６Ｊ小鼠妊娠第１２．５天受到分别为０，０．１０６，０．１５Ｇ，０．３１２，０．５１８和０．６５８Ｇｙ６０Ｃｏγ射线一次性全身照射对其仔代生后生长发育及行为的影响．研究发现：０．５１８Ｇｙ即可使仔鼠宫内体重发育受阻，０．１０６～３．５１８Ｇｙ则可使仔鼠生后的３～２１天龄期间表现出体重增长增加；而生理标志、新生反射和感觉功能以及行为指标的检测，则提示生长发育受阻、行为兴奋性增加的致畸阈值在０．１５６～０．３１２Ｇｙ范围内．

Pregnant adult C57 BL/6J mice were randomly alloted to six experimental groups .Doses of 0, 0. 106,0.156, 0 .312, 0.513 or 0.656 Gyfrom 60Co γ-rays were delivered respectively on the 12. 5th day ofgestation by single radiation except for group 1(used as control). Pups wereobserved for tile growth (body weight, BW ). the age of acquisition of three reflexes (surface righting,SR, negative geotaxis, NG and graspreflex, GR), the apearance of three physiologic markers (eye opening,EO, pinna detachment, PD and incisor eruption, IE) and the sensuous functions(Yisual placinG, VP and mother -taxis, NIT ). And by using these parameters 0. 156 to 0 .312 Gy irradiation may represent a threshold range for exposure on the 12. 5th day of gestation to a single γ-radiation.