浓缩铀内污染诱导免疫细胞的适应性反应

Adaptive response of immunocompetent cells induced by low doses ofinternally deposited enriched uraniun.

作者研究确定低剂量浓缩铀ＵＯ２Ｆ２内污染机体后能否改变相继高剂量浓缩铀ＵＯ２Ｆ２内污染对脾单核细胞白细胞介素－１活性和脾淋巴细胞紫外线诱导的非程序ＤＮＡ合成（ＵＤＳ）的免疫毒理效应。结果发现．低剂量浓缩铀可诱导免疫活性细胞产生适应性反应，使得细胞对高剂量浓缩铀引起的免疫毒理效应如白细胞介素－１活性抑制和紫外线诱导的ＵＤＳ功能降低变得较不敏感．免疫活性细胞适应性反应的诱导具有一定的剂量范畴．诱导适应性反应的剂量与免疫活性细胞的辐射敏感性有关．

The present study engages indetermining whether low doses ofinternally deposited enriched uraniumUO_2F_2 could change the responsiveness of splenic lymphocytes andmonocytes to subsequent higher dosesof enriched uranium UO_2F_2. BALB/cmale mice were injected with 0.01,0.1, 1 or 10 μg/kg body weight ofUO_2F_2. Three days-later the micewere injected with 2 ×10~4μg/kg bodyweight of UO_2F_2. The animals weresacrificed at twenty-four hours afterinjection of higher doses of UO_2F_2.The results show that the splenicmonocytes and lymphocytes exposedto 0.1-10μg/kg or 0 .01-1μg/kg ofUO_2F_2 respectively become lesssusceptible to subsequent higherdoses of UO_2F_2; that is, immunecells exposed to low doses of UO_2F_2become adapted so that less cytoimmane damage represented by variationof unscheduled DNA synthesis andinterleukin-1 is induced by higherdoses of UO_2F_2 .The adaptive responseoccurred only in a limited rangeof low doses of UO_2F_2. The size ofthe induction dose seemed to beinversely related to the radiosensitivity of different immune cells.