Bacillus subtilis MO-L_(010)中ComA蛋白对脂肽合成的影响及高产工程菌株的构建

The Effect of Gene comA Expression on Lipopeptide Synthesis in Bacillus Subtilis MO-L_(010) and Construction of Gene Modified Strain for Lipopeptide Production

脂肽是一类用途广泛的生物活性物质.本文研究了早期感受态基因comA表达对脂肽合成的影响,并据此构建了脂肽高产基因工程菌株,其产量较原菌株提高了约20%,达到450mg/L.

Lipopeptides is a kind of biological active material. They find applications in an extremely wide variety of industrial processes. This paper focuses on the effect of gene comA expression on lipopeptide synthesis and construction of gene modified strain for lipopeptide production. They yield reaches up to 450 mg/L. It is about 20% higher than original strain.