滋养细胞肿瘤患者夫妇外周血G显带染色体的研究

A study on G-bended chromosomes of periperal blood from both trophoblastic tumor patientsand their husbands.

检查了５５例滋养细胞肿瘤患者及４５例患者丈夫和１８１例正常男女对照者的外周血Ｇ显带染色体，重点观察染色体２２号缺失、散发性７；１４号易位和低比例性染色体联合的情况。结果发现，后两者以及９号臂间倒位，在患者夫妇中的发生率均增高，与对照者相比，差异有显著或极显著意义。提示：包括９号臂间倒位、散发性７；１４号易位和低比例性染色体嵌合在内的染色体畸变，可能是滋养细胞肿瘤的发病原因一。

he G-bended chromosomes of peripheral bloodfrom 55 patients with clinically and / or pathologicallydiagnosed trophoblastic tumors,husbands of 45 pa- tients with the disease and 181 female and male nor-mal controls were analyzed.Loss of chromosome22. sporadic translocation of chromosome 7;14 and lowpercentage mosaicism of sex chromosomes were noted. Significantly increased frequencies of the latter twoabnormalities as well as another one,pericentric inver- sion of chromosome 9,were detected in both the pa-tient andthe husbandgroups,suggesting that thesechromosome abnormalities might be causal factors oftrophoblastic tumors.