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卡前列甲酯栓剂用于妊娠晚期引产的临床观察 被引量:30

15-methyl -PGF_(2α) vaginal suppository for in-duction of term labor
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摘要 应用卡前列甲酯(PG_(05))、前列腺素E_1马类药物(ONO-802)阴道栓剂及催产素,对99例单胎头位初产妇(随机分为三组,每组33例)进行妊娠晚期引产效果的对比观察,并随机抽取其中30例,测定其引产前后血浆前列腺素(PGE_2、PGF_(2α)水平。结果:引产总有效率:PG_(05)组为88%,ONO-802组为100%,催产素组为79%,三组比较,差异无显著性(P>0.05),各组引产前后血浆前列腺素水平变化,差异也无显著性。提示:PG_(05)用于妊娠晚期引产是安全有效的。 he results of intravaginal 15- methyl PGF_(2α)(PG_(05))were compared with gemeprost (ONO-802,PGEI analogue) pessary and oxytocin intravenous in-fusion for induction of labor at term.A total of 99primipara with singleton pregnancy and cephalic pres-entation, accepted for induction,was randomly allo-cated into 3 groups:group 1, PG_(05) 0.25mg(n=33),group2,ONO- 802 0.125mg(n=33),and group3,oxvtocin i.v. (n=33).Among these,30 cases hadplasma PGs (PGE2 and PGF_(2α) )concentration deter-mined before and after induction. Successful treatmentwas defined as active labor sturting within 24 hoursfollowing induction or an increase of cervical Bishopscore>3. The success rates were not significantlydifferent among the 3 groups(PG_(05) 88%,ONO-802 100%,and oxytocin 79%),(P>0.05).No significant difference existed in the plasmaprostaglandin concentrations as well.It is sug-gested that PG_(05)may be used for induction oflabor at term.
出处 《中华妇产科杂志》 CAS CSCD 北大核心 1994年第5期273-275,共3页 Chinese Journal of Obstetrics and Gynecology
关键词 前列腺素 引产 药物引产 栓剂 Prostaglandins,synthetic Labor,induced Pregnancy trimester,third.
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