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卵巢浆液性和粘液性肿瘤共享结肠癌抗原决定簇 被引量:1

Sharing antigenic determinant of colon carcinoma between serous and mucinous tumorsof the ovary
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摘要 以抗结肠癌单克隆抗体SC13A为探针,应用免疫组织化学染色法,分别对67例卵巢浆液性和44例卵巢粘液性肿瘤组织,以及20例正常卵巢组织中相应的抗原表达进行检测。结果:在浆液性囊腺瘤、交界性囊腺瘤和乳头状囊腺癌中SC13A抗原的表达率分别为8.0%,71.4%和90.0%;在粘液性囊腺瘤、交界性囊腺瘤和乳头状囊腺癌中SC13A抗原的表达率分别为25.8%、80.0%和87.5%;正常卵巢组织中无3C13A抗原表达。浆液性、粘液性的交界性囊腺瘤和乳头状囊腺癌的抗原表达率,均显著高于浆液性、粘液性囊腺瘤及正常卵巢组织(P<0.005)。提示:浆液性和粘液性肿瘤抗原之间有内在的联系,这两类肿瘤的抗原中均共同享有与结肠癌抗原相同的抗原决定簇,这种抗原位点在恶性肿瘤中的表达明显高于良性肿瘤。 xpression of colon-ovarian tumor antigen(COTA) in serous and mucinous tumors of the ovarywas determined immunohistochemically, usingmonoclonal antibody SC13A against colon carcinomaantigen as a probe. In 67 serous tumors of the ovary,the frequency of expression was 90.0% in thecystadcnocarcinomas, 71.4% in the borderline cys-tadenomas, and only 8.0% in the cystadenomas. In 44mucinous tumors of the ovary, the SC13A marker wasexpressed in 87.5% of the malignant tumors, 80.0% ofthe borderline tumors, and 25.8% of thebenign cystadenomas. And in 20 samples of normalovarian tissue a negative immunostaining for theSC13A was found. These findings showed that theserous and the mucinous tumors share the sameantigenic determinant of colon cancer, and the percen-tage expression of which is significantly higher in themalignant than in the benign and the borderline tu-mors. as well as in the normal ovarian tissues(P< 0.005). The marker might be valuable for furtherstudies of these tumors.
出处 《中华妇产科杂志》 CAS CSCD 北大核心 1994年第7期398-400,共3页 Chinese Journal of Obstetrics and Gynecology
关键词 抗原 决定簇 卵巢肿瘤 结肠肿瘤 Antigenic determinant Tumormarker, bilolgical Ovarian neoplasms Colonicneoplasms Antibodies, monoclonal
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参考文献6

  • 1刘民培,中国肿瘤,1993年,11卷,27页
  • 2江森,中华妇产科杂志,1992年,27卷,323页
  • 3刘民培,中华肿瘤杂志,1992年,14卷,6页
  • 4刘民培,中华肿瘤杂志,1992年,14卷,91页
  • 5马世英,免疫学杂志,1991年,7卷,265页
  • 6马世英,中国实验临床免疫学杂志,1991年,5卷,15页

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