尿促性腺激素片段在滋养细胞疾病监测中的意义

Uruiary gonadotropin fragment measurement in the moiutoring of trophoblasticdisease .

对４６例滋养细胞疾病患者尿标本２７５份进行尿促性腺激素片段（ＵＧＦ）测定，并自身对照收集同期血标本２７５份，测定绒毛膜促性腺激素（ｈＣＧ），并进行比较。另选１２例健康非妊娠妇女为对照组。结果，滋养细胞疾病患者尿ＵＧＦ阳性串（＞０．２μｇ／Ｌ）为６４．０％，血清ｈＣＧ阳性率（＞２０μｇ／Ｌ）为６６．５％，两者差异无显著性（Ｐ＞０．１）。血清ｈＣＧ阴性患者中，尿ＵＧＦ阳性者５７．６％。提示在滋养细胞疾病患者血ｈＣＧ呈高值时，尿ＵＧＦ阳性率亦高，测定意义不大。而血ｈＣＧ呈低值、ｈＣＧ阴性时，尿ＵＧＦ仍有一定的检出率。对照组１２例无假阳性。

rinary gonadotropin fragment (UGF)is a small peptide which is present in the urine of pregnantwomen and of women with trophoblastic diseases aswell as with certain nontrophoblastic inalignancics. 尿促性腺激素片段(urinary gonadotropin275 saniples each of urine and blood from 46 patientswith trophoblastic diseascs werc takcn for UGF andhCG measurements and compared. 24 samples from12 healthy, nonpregnant women were taken as control.Cut-off values of UGF and hCG ued for incasuringthe sensitivity of trophoblastic diseases wererespotively >0.2 μg / L and abovc 20μg / L. It wasfound that 64.0% of the urine saniples gave UGF val-ues >0.2μg /L and 66.5% of the blood sainplesshowed hCG levels above 20pg/L (P>0.1). Nofalse-positive rate was obscrved in the control group.However, among patients who were found to have lowor negative hCG valucs, 57.6% showcd peaitive UGFlevels. These findings suggest that in paticnts with pos-itive levels of both UGF and hCG, the UGFmeasureinent may not be necessary. But for patientswith low or negative blood hCG values, ccrtain per-centage of urine UGF could still be dctected.