小剂量生长激素在体外受精超排卵周期中的作用

The effect of co-administration of low dosage growth hormone and gonadotropin for ovarian hyperetimulation in vitro fertilization and em-bryo transfer

在体外受精－胚胎移植（ＩＶＦ－ＥＴ）超排卵周期中，对反应差的不育妇女２７例采用促性腺激紊释放激素激动剂（ＧｎＲＨ－ａ）／小剂量重组人生长激奈（ＧＨ）结合人绝经期促性腺激奈（ｈＭＧ）／人绒毛膜促性腺激素（ｈＣＧ）进行超排卵１２例（ＧＨ组），与采用ＧｎＲＨ－ａ／ｈＭＧ／ｈＣＧ的１５例（对照组）进行比较。结果表明，ＧＨ能促进卵母细胞成熟，提高受精率，增加移植胚胎数，明显提高妊娠率。但未能影响卵泡的招募及诱发排卵所需ｈＭＧ的剂量和用药时间。血清胰岛素样生长因子Ｉ（ＩＧＦ－Ｉ）的水平在使用ＧＨ期间从１５０±４４ｎｇ／ｍｌ升达２２２±６ｎｇ／ｍｌ（Ｐ＜０．０１），而对照组无类似变化。证实小剂量ＧＨ在体外受精超排卵周期中的使用是有效的。

he co-administration of low dosage growthhormone (GH) and gonadotropin (Gn) to women withsuboptimal respouse to GnRH-a/hMG/bCGhyperstimulation regimen during previous cycles ininvitor fertilization-enibrgo transfer (IVF-ET) might be beneficial by promoting the maturation of oocytes,improving the fertilization rate and increasing thenumber of embryos replatal. Our results showed thepregnancy rate increascd significantiy. Howcver, thisprotocal neither enhaned ovarian response to Gn, norreduced Gn dosae required for follicular recruitment.The levels of insulin-like growth factor I(IIGF-I) inthe co-treatment group increased from 150±44μg / L to 222 ± 46 pg / L (P < 0.01 ) during theadmiliistration of GH , Thesc . incrcasedsignificantly as compared with the control group.The present study showed that tbe administra.tion of GH in low doses is effective.