内窥镜手术结合干扰素治疗小儿喉乳头状瘤的临床观察

Curative effect of endoscopic surgery combined with interferon subcutaneous injection on juvenile laryngeal papillomatosis

目的了解内窥镜手术结合α-干扰素治疗小儿喉乳头状瘤的临床价值。方法38例在支撑喉镜下用内窥镜进行喉乳头状瘤手术(术中用咬除或吸割器切除肿瘤),手术创面液氮冷冻处理,术后定期皮下注射α-干扰素;同期支撑喉镜下仅作喉乳状瘤单纯切除20例。对所治病例的临床资料进行分析。结果应用内窥镜手术,术中可清晰显示喉腔内病灶的部位,同时能处理气管内的病灶,术后连续皮下注射α-干扰素随诊1.5-2.5年,2年治愈率达70.3%;支撑喉镜下单纯肿瘤切除者,2年治愈率为38.1%,二组疗效差异有显著意义(P<0.05)。结论内窥镜手术及术时创面液氮处理配合术后应用α-干扰素,使小儿喉乳头状瘤治愈率比既往手术治愈率有较大提高。

Objective To evaluate the curative effect of endoscopic surgery combined with interferon subcutaneous injection on juvenile laryngeal papillomatosis. Methods Thirty-eight children with laryngeal papillomatosis underwent endoscopic papillomaectomy with wound surface treated with liquefied nitrogen, and were injected with interferon subcutaneously periodically after operation. Twenty children underwent papillomaectomy in supportive laryngoscope without other treatment at the same stage. The curative effect were recorded and analyzed in two years' follow-up visit. Results The curative effect in two years was 70. 3% in children who underwent endoscopic surgery combined with interferon subcutaneous injection and was higher than 38. 1% in children who underwent papillomaectomy in supportive laryngoscope, P<0.05. Conclusions Endoscopic surgery combined with interferon subcutaneous injection periodically canenhance curative rate in juvenile laryngeal papillomatosis compared with the traditional surgery.