甘利欣和香丹注射液治疗高中应届生ALT超标的观察

Curative effect of diammonium glycyrrhizinate and xiangdan in treatment of senior school three-grade students with ALT heighteningi

目的观察甘利欣(甘草酸二铵)及香丹(复方丹参)注射液联用治疗丙氨酸氨基转移酶(ALT)超标学生的临床快速疗效。方法对高三学生体检时出现ALT≥50U/L的病例分组治疗。治疗组:甘利欣注射液30mL(150mg)+5%GS250mL,香丹注射液30mL+5%GS250mL静脉注射,口服药物肝太乐、联本双脂、降酶灵等药;对照组:肝太乐0.4g+5%GS250mL、肝安注射液250mL静脉注射,口服药物同治疗组;自选组:患者或家属自选医生治疗。各组用药7d复查ALT。结果治疗7d,治疗组:17例ALT全部恢复正常,ALT平均下降度65.69%;有效率100%;对照组:16例ALT12例下降,恢复正常9例,增高、持平各2例,ALT平均降幅37.61%;7例无效,有效率56.25%;自选组:10例ALT恢复正常7倒,增高3例,ALT平均降幅46.09%:3例无效,有效率70.00%;治疗组与对照组比较:ALT平均降幅46.09%;3例无效,有效70.00%;治疗组与对照组比较:ALT下降幅度P<0.005(t=3.239),治疗有效率P<0.005(t=3.104),治疗组与自选医生相比较:ALT下降幅度P<0.05(t=2.021);治疗有效率P<0.05(t=2.510)。对照组与自选组比较:ALT下降幅度(t=0.619)和治疗有效率(t=0.705)差异无显著意义。治疗组的复常率100%。结论甘利欣、香丹注射液联用治疗ALT超标患者比肝太乐、肝安注射液联用的效果显著,ALT降幅和有效率均有极显著意义。

Objective To study the curative effect of diammonium glycyrrhizinate and xiangdan injections in the treatment of students with ALT heightening. Methods The senior school three-grade students whose ALT≥50 U/L were divided into three groups, which were therapy group: diammonium glycyrrhizinate injection 30 mL (150 mg) + 5% GS 250 mL/iv drip, qd, xiangdan (tanshinone compound) injection 30 mL + 5% GS 250 mL/iv drip, qd, and glucurone, bifendate, giangmeiling et al. PO; control group: glucurone 0.4 g +5% GS 250 mL/iv drip, qd, 15-amino acid injection 250 mL/iv drip, qd, and other drugs as the same in the therapy group; optional group: sufferers or family numbers optionally saw doctors on therapy. After seven days, ALT was re-examined. Results After 7 days of the therapy, ALT recovered to normal in all the 17 cases in the therapy group, the extent of ALT dropped by 65.69% averagely, and the effective rate was 100%. In the control group (16 cases), ALT dropped in 12 cases, in which 9 cases recovered to normal, the extent of ALT dropped by 37.61 % averagely, 7 cases were ineffective, and the effective rate was 56.25%. In the optional group (10 cases), ALT dropped to normal in 7 cases, ALT heightened in 3 cases, the extent of ALT dropped by 46.09% averagely, 3 cases were ineffective and the effective rate was 70.00%. Compared with the control group, the extent of ALT in the therapy group dropped significantly, t = 3.239, P<0.005 and the effective rate was higher in the therapy group than that in the control group, t = 3.104, P<0.005. Compared with the optional group, the extent of ALT in the therapy group dropped more significantly, t=2.021, P<0.05, and the effective rate in the therapy group was higher than that in the optional group, t = 2. 510, P < 0. 05. While the control group was compared with optional group, there were no significant differences in the dropping extent of ALT (t = 0.619) and the effective rate (t = 0.705). The renewed normal rate was 100 % in the therapy group. Conclusions The curative effect of diammonium glycyrrhizinate and xiangdan injections is much better than that of glucurone and 15-amino acid injections in the treatment of students with ALT heightening, and there are significant differences between them in the ALT dropping extent and effective rate.