正常妊娠妇女外周血可溶性白细胞介素－2受体及淋巴细胞亚群的变化

Serum level of soluble interleukin-2 receptorand T lymphocyte Suhpopulations in normalprapsnty

测定了８７例妊娠晚期及２９例正常非孕妇女外周血可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）水平，同时对其中３６例孕妇及１０９例正常非孕妇女（正常对照）进行外周血淋巴细胞亚群检测。结果：妊娠晚期妇女ｓＩＬ－２Ｒ水平及Ｔｓ细胞（ＣＤ＿８）明显高于正常对照，分别为：２１４６００±７０４００Ｕ／Ｌ比１６２１００±８４１Ｄ０Ｕ／Ｌ， Ｐ＜０．０１及３７．６％±５．３％比３１．３％±７．０％，Ｐ＜０．０１。妊娠妇女Ｔｈ细胞／Ｔｓ细胞（ＣＤ＿４／ＣＤ＿８）比例明显低于正常对照（１．２±０．２比１．５±０．５，Ｐ＜０．０１）。但总Ｔ淋巴细胞（ＣＤ＿３），ＣＤ＿４，细胞与正常对照相比，差异无显著性，分别为：６４．１％±７．３％比６６．０％±９．９％，Ｐ＞０．０５及４４．１％±５．８％比４３．８％±９．Ｏ％，Ｐ＞０．０５。相关分析表明孕妇ｓＩＬ－２Ｒ水平与ＣＤ＿３、ＣＤ＿４、ＣＤ＿８细胞及ＣＤ＿４／ＣＤ＿８均无显著相关性（ｒ分别为０．２０３２，０．２０７７，０．１０３７及０．１２１４，Ｐ均＞０．０５）。提示：孕妇外周血Ｔ淋巴细胞亚群及血清ｓＩＬ－２Ｒ的变化对维持正常妊娠有重要作用，ｓＩＬ－２Ｒ可能是促进胎儿正常生长的重要介质之一。

erum soluble interleukin-2 receptor (sIL-ZR) lev-els and T lymphocyte subpopulations were measured in87 cases of normal pregnancy and 109 normal non-preg-nant women as control group. It was found that sIL-2Rlevel and CDS T subpopulation increased as comparedwith control group (214 600±70 400U/L vs 162 100±84 100U/L, P< 0. 01; 37. 6%±5. 3% vs 31. 3%±7.0%,,P<0. 01) , but the ratio of CD4/CD8 was lowerthan that of control group ( 1.2±0. 2 vs 1. 5±0. 5 ,P<0. 01). No significant difference was found betweenCD3 , CD4 subpopulations of pregnancy and that of con-trol group (64. 1%± 7. 3% vs 66. 0%±9.9%,P>0. 05 ; 44. 1%±5. 8%…… vs 43. 8%±9. 0 %, P>0.05).And no significant relation was found between sIL-2Rlevel and CD3 , CD4, CD8 subpoplations, CD4lCDS (r= 0. 203 2, 0. 207 7 , 0. 103 7, 0. 121 4 respectly, P>0. 05 ). These results suggested that the changes of Tlymphocytes and sIL-2R may play an important role inmaintaining normal pregnancy and slL-2R may be oneof factors improving fetal survival.