利福喷丁在脊椎结核寒性脓肿中浓度的测定

The concentration of RFT in cold abscesses in pa-tients with spinal tuberculosis

采用生物学法测定了１１例脊椎结核病人寒性脓肿与其血清中利福喷丁（ＲＦＴ）的浓度，病人顿服ＲＦＴ６００ｍｇ后，分别在４、８、１２、２４、４８、７２、９６、１２０和１４４小时，收集静脉血和寒性脓肿液测定ＲＦＴ的浓度。实验结果显示国产ＲＦＴ口服后吸收良好，在脊椎结核寒性脓肿中ＲＦＴ有效抑菌浓度（ＭＩＣ）可维持９６小时，说明ＲＦＴ作为治疗骨关节结核间歇给药有效的药物。

AbstractThe concentrations of RFT in cold abscessesand serum were assessed microbologically in 11 pa- tient with spinal tuberculosis, The specimens of ab- scess aspiration and venous blood were collectedfrom each patients at 4,8,12,24,48, 72,96,120 and144 hours after the administration of 600 mg ofRFJ.The labortory data showed that the concen-trations of RFT in cold adscesses could be main-tained at bacteriostatic level(0.0i85±0.213g/ml)for 96 hours. The authors concluded that the sys- temic intermittent chemotherapy with RFT ratherthan routlne use of antituberculous drugs is applica-ble.