退行性心脏瓣膜病与心力衰竭关系的临床研究

Clinical studies on the relationship between senile degenerative valvular heart disease and heart failure

目的:研究退行性心脏瓣膜病(SDVHD)与心力衰竭(简称心衰)的关系。方法:86例SDVHD患者与86 例性别、年龄和基础疾病及程度相配对的对照组相比较,观察两组心衰发生情况。所有研究对象的超声心动图检查均由专人负责,采用美国Acuson128/P/10ART多功能电脑彩色多普勒超声诊断仪检查,采取统一诊断标准,随访观察心衰的发生情况。结果:SDHVD组左心衰65例(75.5%)、全心衰19例(22.0%),较对照组(14例(16.2%)、6例(7.0%)]增加,而射血分数(EF)较对照组显著降低[(43±7)%vs(71±6)%,P<0.01]。结论: 本研究结果提示SDHVD可促发和加重心衰,是临床上心衰的重要因素之一。

Objective: To investigate the relationship between senile degenerative valvular heart disease (SDVHD) and heart failure. Methods:86 cases of SDVHD consisted of 67 males and 19 females, with the mean age of 60 -93(78±9)yr . 86 cases of controls with comparable gender, age and baseline conditions were include in the control group. Morbidity rate of heart failure were compared between the two groups during 12 years follow-up. Heart function was determined by color Doppler ultrasonography. Results:Prevalence of left heart failure and whole heart failure in SDVHD group were 75. 5% and 22. 0% , respectively, significantly higher than the control group ( 16. 2% and 7. 0% , respectively). Ejection fraction ( Ef) in SDVHD group was significantly lower than the control group [ (43±7 ) % vs (71±6)%,P<0.01]. Conclusion: SDVHD may induce and exacerbate heart failure.