医院感染中常见病原菌耐药分析

Analysis and surveillance of drug-resistant bacteria in hospital infection

目的观察和监测深圳西丽地区医院感染中常见病原菌对抗菌药物的耐药情况。方法收集本区2003年1月至2004年12月各类临床住院标本985株,其中革兰阳性球菌511株,革兰阴性杆菌474株。采用法国生物梅里埃ATB体外药敏测试条进行药物敏感试验,耐药数据分析采用WHONET5软件。结果引起医院感染的主要病原菌是大肠埃希菌、金黄色葡萄球菌、肺炎克雷伯菌、表皮葡萄球菌、溶血性葡萄球菌、缓症链球菌、肠球菌。耐苯唑西林的金黄色葡萄球菌的分离率为21.8%,明显低于国内其它城市,耐苯唑西林的凝固酶阴性的表皮葡萄球菌的分离率为76%,耐苯唑西林的凝固酶阴性的溶血性葡萄球菌的分离率为90%。金黄色葡萄球菌,表皮葡萄球菌,缓症链球菌对万古霉素的敏感率为100%,肠杆菌科细菌对美洛匹宁、阿米卡星的耐药性最低。结论抗生素的不合理应用可加重病原菌的的耐药,对细菌耐药性的监测,可为临床合理用药提供依据。

Objective To investigate drug resistance of clinical bacteria isolates. Methods From January 2003 to December 2004,a total of 985 bacteria isolates were isolated from the patients.ATB test was used to study the antimicrobial resistance.WHONET5 was applied for analysis.Results A total of 985 pathodenic rains including 52% Gram-positive cocci and 48% Gram-negative bacilli bacteria isolates were obtained,E.coli,S.aureus,K.pneumoniae,and S.epidermidis were the most common strains among the isolates.Oxicillin-resistant S.aureus and oxicillin-resistant S.epidermidis were 21.8%and 76% respectively.MRSA,MRSE were susecptibal to vancomycin(100%).Entenobacteriaceas were susceptible to meraopenem and amikacin. Conclusion It is important to promote the rational use of antimicrobial by surveillance of drug-resistant becteria.