摘要
为探讨胆汁返流性胃炎的发病机理和应用中药治疗此病的效果，作者进行了胃粘膜超微结构观察。在治疗前、后取胃粘膜做光、电镜检查，发现本病胃粘膜变化突出的特点是淋巴细胞侵入腺细胞内，溶解腺细胞，破坏细胞间联接装置，使腺腔破溃，腺管萎缩。以上变化可占全部病例的８７．５％。另一特点是腺细胞内出现微囊（８例中有４例），这在慢性胃炎尚未见有电镜观察报道。作者认为胆汁返流性胃炎可以是慢性萎缩性胃炎的前驱，而腺体萎缩的原因是由于淋巴细胞的浸润破坏；这为由细胞介导引起的胃腺细胞损伤提供了形态学依据。
he structural changes of gastric mucosa in bile
reflux gastritis were examined with both optic and electron microscope before and after the
treatment.The significant find-ings were:①In 87.5%of the cases,there were lymphocytic
invasion into the gland cells,which led to cell dissolution and disrupture of intercellular
connections,resulting in gland cavity destruction and glandular duct atrophy;and②The
appearance of micro sac inside the gland cells in 4 out of 8 cases,which had never been
reported seen by elec tron microscope in chronic gastritis before. The authors consider that
bile reflux gastri-tis can be the pre-stage of chronic atrophic gastritis,whereas the gland atrophy
is th result of lymphocytic destructive invasion,and thus provided the morphologic evidence of
cell-mediated gastric gland injury.
