固定复合制剂治疗肺结核患者依从性分析

A study on patients’ compliance of fixed-dose combination (FDC) in anti tuberculosis treatment

目的探讨肺结核患者对固定复合制剂(FDC)治疗的依从性及影响因素。方法选择新发涂阳肺结核患者373例,其中FDC组232例,对照组141例,并对治疗期间的患者进行问卷调查。结果46.0%FDC组患者认为药片数合适,51.2%认为药片大小合适,均高于对照组患者(21.9%与34.4%)(P<0.05)。与对照组相比,更多的FDC组患者认为服药方式可以接受的比例(96.9%)高于组合药(82.4%),两者间差异具有统计学意义(P<0.05)。两组吞服时,药片粘喉、苦味方面没有显著性差异。FDC组的AST异常率(33.3%)比对照组高(20.0%),而TBIL的异常率(6.2%)比对照组低(15.4%)(P<0.05);FDC组的治愈率(93.1%)比对照组高(86.0%)(P<0.05)。结论相对于对照组药物,患者对FDC的依从性更好。

ObjectiveTo evaluate patients' compliance and effective factors of Fixed dose Combination (FDC) in anti tuberculosis therapy. Methods374 cases who were diagnosed as new smear positive pulmonary tuberculosis were allocated into two groups: FDC treatment group (n=232),and control group(n=141).The side effect of that were strictly supervised by doctor. Results51.2% and 46.0%of FDC group thought the size and number of pills were suitable,and 96.9% of FDC group accepted the procedure of taking medicine (P< 0.05 ). But there were almost no difference between two groups in deglutition of pills, bitter and pills' viscidity in throat.No significant difference could be found between two groups about adverse reactions. From laboratory test result:Abnormity rate of AST in FDC group (33.3%)was higher than in controlled group(20.0%), and Abnormity rate of TBIL in FDC group (6.2%)was lower than in FDC group(15.4%) (P<0.05).The distribution of ALT, AST, TBIL was consistent in patients of abnormal test result of hepatic function in two groups.The cure rate of FDC group (93.1%)was higher than that of controlled group(86.0%).ConclusionsFDC can improve compliance of patients in anti tuberculosis therapy.