Auto-CPAP治疗阻塞性睡眠呼吸暂停综合征对睡眠结构的改善

Improvement of sleep structure in patients with obstructive sleep apnea hypopnea syndrome treated by auto-continuous positive airway pressure

目的观察自动调节压力智能型持续正压通气(Auto-CPAP)治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的疗效,并探讨其对睡眠结构的影响。方法研究28例OSAHS患者用AUTO-CPAP治疗前、治疗时的多导睡眠图各参数的变化。结果治疗时呼吸暂停低通气指数(AHI)由(54.4±22.7)/h降至(8.0±8.7)/h(P<0.001),最长呼吸暂停时间由(57.6±18.3)s缩短为(25.6±12.9)s(P<0.001),最低血氧饱和度明显改善由(66.0±12.1)%升高到(83.7±9.1)%(P<0.001),平均血氧饱和度也明显改善由(86.5±6.8)%升高到(93.6±2.2)%(P<0.001);治疗同时患者的睡眠结构:深睡眠(3,4期)比例明显增加由(5.4±8.0)%增加至(11.4±5.4)%(P<0.01),微觉醒指数(MAI)明显降低由(31.5±19.5)/h降至(8.3±5.1)/h(P<0.001),睡眠效率有所降低由(89.8±9.1)%降至(85.0±11.8)%(P<0.05)。结论AUTO-CPAP能明显改善OSAHS患者的呼吸暂停、AHI及夜间缺氧状况,AUTO-CPAP同时也改善了OSAHS患者的睡眠结构。

[Objective] To observe the efficiency of auto-continuous positive ai rway pressure(Auto-CPAP) treatment in patients with obstructive sleep apnea hypo pnea syndrome(OSAHS). And to investigate the influence of sleep structure in OSA HS patients treated by AUTO-CPAP. [Methods] The polysomnography (PSG) were tak en in 28 patients with OSAHS untreated previously. Their parameters of PSG obtai ned before and during the AUTO-CPAP treatment were analyzed. [Results] During the AUTO-CPAP treatment the longest apnea time had been shorten (25±12.9) s vs. (57.6±18.3) s, P <0.001. Apnea Hypopnea Index(AHI) had been decreased(8.0±8.7 )/h vs. (54.4±22.7)/h, P <0.001. The lowest oxygen saturation had been raised ( 83.7±6.5) % vs. (66.0±12.1) %, P <0.001. And the average oxygen saturation imp roved too (93.6±2.2)% vs. (86.5±6.8)%, P <0.001). The deep sleep (sleep stage 3 and 4) improved (11.4±5.4)% vs. (5.4±8.0), P <0.01. Microarousle Index (MAI ) decreased from (31.5±19.5)/h to (8.3±5.1)/h (P <0.001). Sleep efficiency get a little lower (85.0±11.8) % vs. (89.8±9.1) %, P <0.05. [Conclusions] Auto- CPAP can improve the sleep apnea/hypopnea and noctural oxygendesaturation. The s leep quality of OSAHS patients improved too during treating.