非淋菌性尿道炎患者支原体、衣原体感染及体外耐药性分析

Study on Infection and Drug Resistance to Antibiotics in Vitro of Ureaplasma urealyticum,Mycoplasma Hominis and Chlamydia Trachomatis in Patients with Non-Gonococcal Urethritis

目的:比较不同性别患者标本中支原体和衣原体分离率及对九种抗生素的耐药性,指导临床合理用药。方法:采用IST和ChemtrueTM试剂盒对353例疑为NGU患者的泌尿生殖道标本进行了支原体和衣原体检测,同时对支原体检测阳性标本进行了菌落计数和抗生素敏感性检测。结果:353例标本中支原体和衣原体分离率为37.4%,其中男性标本中支原体和衣原体分离率为23.9%,女性标本中支原体和衣原体分离率为45.7%。Uu的菌落计数结果,≥104cfu/ml比例女性(48.6%)与男性(48.0%)基本相同。Mh的菌落计数结果,≥104cfu/ml比例女性(31.0%)与男性(30.0%)基本相同。支原体对MIN、DOX耐药性较低,对JOS、CLA、ROX、AZI、OFL、LEV、SPA的耐药率女性和男性标本各不相同。结论:NGU患者中支原体和衣原体是主要的病原,监测支原体的耐药性对指导临床治疗具有重要意义,MIN、DOX可作为治疗支原体感染NGU的首选药物。

Objective To evaluate the occurrence of Ureaplasma urealyticum(Uu) and Mycoplasma hominis(Mh)and Chlalnydia trachomatis(CT),and to analysis the drug resistance to 9 antibiotics of Mh and Uu,to determine the most suitable treatment strategy.Methods CT in genitourinary tract of 353 NGU patients was detected by kit of Chemtru TM .Uu and Mh in genitourinary tract was detected by kit of IST.Results In 353 tested samples,37.4 % were Mycoplasma and Chlamydia positive.In 134 virility tested samples,23.9 % were Mycoplasma and Chlamydia positive.In 219 female tested samples,45.7 % were Mycoplasma and Chlamydia positive.In 134 virility tested samples,48.0 % were Uu≥10 4 cfu/ml,30.0 % were Mh≥10 4 cfu/ml;In 219 female tested samples,48.6 % were Uu≥10 4 cfu/ml,31.0 % were Mh≥10 4 cfu/ml.The drug resistance of Mycoplasma to Minocycline and Doxycycline was very low,which of Mycoplasma to other antibiotics was different.Conclusion In genitourinary tract,Mycoplasma infections is taller than Chlamydia infections.Resistance monitoring of Mycoplasma periodically has important significance in clinical drug treatment.