摘要
应用DNA斑点杂交技术对44例大肠癌及相邻正常粘膜组织C-myc癌基因扩增进行分析,探讨C-myc扩增与大肠癌分化程度及Dukes分期的关系.结果表明:大肠癌C-myc扩增率为61.4%.并与分化程度密切相关,粘液腺癌和低分化腺癌的扩增率明显高于高分化腺癌.C-myc扩增可作为大肠癌的一项有价值的生物学标志.
Abstract An amplification of c-myc oncogene was investigated hybridizatially in 44 colorectal carcinoma tissues and their adjacent normal colon mucosa. The correlation of amplification with tumor grade of differentiation and Dukes stage was analysed. DNA dot-blot hybridization showed 2 ̄ 7 fold amplification of the c-myc gene in 61 .4% tumor, and statistical analysis revealed a significant correlation between c-myc and grade of tumors. An amplification ratio of c-myc was 84.6% in mucinous carcinoma, and 71 .4% in poorly differentiated tumors.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
1994年第2期109-110,共2页
Chinese Journal of Nuclear Medicine