摘要
目的探索人胚腺垂体移植治疗垂体性侏儒症的新途径。方法选用妊娠20～28周水囊引产人胚腺垂体经腰穿方法移植于Ⅰ型垂体性侏儒症患者的椎管下段蛛网膜下腔。结果治疗23例,经1～5年随访,复查激素水平均有不同程度升高,1年身高增长2～4cm14例,4～6cm9例,其中3例5年内共移植3次,身高分别增长18cm、16cm和13cm,其他相应体征明显改善。结论人胚腺垂体椎管蛛网膜下腔移植治疗垂体性侏儒症有显著疗效。
Objective To investigate the method of treating hypophysial dwarf by transplantation of embryonic anterior pituitary cells. Methos Transplanting embryonic anterior pituitary cells to vertebral canal subarachnoid space in the treatment of hypophysial dwarf of type Ⅰ. Results Twenty-three cases of hypophysial dwarf of type I were performed with transplantation of embryonic anterior pituitary cells to vertebral canal subarachnoid space. The follow up was 1～5 years, the body height in treatment patients increased for 3～4 cm, the growth hormone level was increased. Conclusion The transplantation of embryonic anterior pituitary cells to vertebral subarachnoid space is effective in the treatment of hypophysial dwarf.
