葡萄籽原花青素耐缺氧作用的实验研究

Preliminary Research of Grape Seed Proanthocyanidins's Effect on the Role of Hypoxic Tolerance in Mice

目的 观察葡萄籽原花青素(GSP)的耐缺氧作用。方法 采用小鼠常压耐缺氧实验和小鼠断头实验,观察GSP对缺氧小鼠存活时间、耗氧量及断头后张口喘气时间的影响。结果 GSP能明显延长常压缺氧小鼠的存活时间及脑缺氧小鼠张口喘气时间,降低耗氧量。结论 GSP具有耐缺氧作用,其作用机制可能与增加大脑供血和降低心脑耗氧有关。

Objective To observe the effect of grape seed proanthocyanidins(GSP) on the role of hypoxic tolerance in mice.Methods Acute anoxia in mice were produced by hypoxia under normal pressure and decapitation.In these two models the effect of GSP on survival time,persistent time of gasping and oxygen consumption were observed.Results GSP significantly prolonged the survival time,persistent time of gasping and decreased oxygen consumption in mice subjected to acute anoxia and decapitation.Conclusion GSP has hypoxic tolerance role that may relate to increasing cerebral blood and reducing the cardiac and cerebral oxygen consumption.