转接蛋白NTAL/LAB在淋巴细胞发育和活化中的作用

NTAL/LAB:immuno-regulatory role in lymphocyte development and function

由膜受体介导的信号转导过程在淋巴细胞发育、分化和活化过程中起着重要的作用,转接蛋白是淋巴细胞信号转导中发挥承上启下作用的分子。它们被相应的蛋白酶磷酸化后,可以通过招募具有特定氨基酸基序的蛋白质,将信号转导通路中不同阶段的分子募集在一起,从而实现信号的整合和分流。NTAL/LAB是新发现的跨膜转接蛋白,体外B细胞受体、FcγRI和FcεRI受体的交联可以引起该分子的迅速磷酸化,提示NTAL/LAB可能参与了这些受体介导的信号转导途径,从而影响淋巴细胞的发育和功能。本文将对NTAL/LAB在主要淋巴细胞发育和分化中的作用作一介绍。

Adaptor proteins mediate protein-protein and protein-lipid interactions. They play a pivotal role in organization and assembly of immunoreceptor-initiated signaling during the development and activation of lymphocytes. Upon phosphorylation by proper kinases, they can recruit certain proteins and act as molecular scaffolds through which multiprotein signaling complexes are assembled via signaling motifs (e.g. Src homol- ogy 2 (SH2)-, Src homology 3 (SH3)-, pleckstrin homology (PH)-domains). The recently identified transmem- brane adaptor protein NTAL (non-T cell activation linker)/LAB (linker for activation of B cells) facilitates our understanding of how this protein regulates signaling within activation and differentiation of lymphocytes.