沙培林治疗老年肺癌所致恶性胸腔积液的疗效观察

Clinical observation on OK-432 in treatment of malignant pleural effusion induced by lung cancer in elderly

目的探讨沙培林治疗高龄老年患者恶性胸腔积液的疗效及不良反应。方法72例诊断肺癌恶性胸腔积液的老年患者,分为沙培林组42例和白细胞介素2(IL2)组30例,患者行胸腔穿刺术或胸腔置管引流术后胸腔内分别注射沙培林,每次1～10KE,和IL2,每次200万U,4w后观察疗效及不良反应。同时将沙培林组分为两组(>75岁组和≤75岁组),并进行疗效的比较。结果沙培林组有效率85.7%(36/42),明显高于IL2组有效率63.3%(19/30)(P<0.05)。不同年龄组应用沙培林治疗恶性胸腔积液,两组疗效无明显差异(P>0.05)。结论胸腔内注射沙培林治疗老年患者,特别是高龄老年患者恶性胸腔积液疗效肯定,是控制恶性胸腔积液的有效方法。

Objective To evaluate the therapeutic effect and adverse reactions of OK-432 in treatment of the malignant pleural effusion in the elderly.Methods 72 elderly patients diagnosed as malignant pleural effusion induced by lung cancer were divided into OK-432 group (n=42, intracavity injection of OK-432, 1~10 KE per time) and IL-2 group (n=30, intracavity injection of IL-2, 2×10~7 U per time). The therapeutic effect and adverse reactions were observed after four weeks. Meanwhile,42 patients treated with OK-432 were divided into >75 years group and ≤75 years group to compare their therapeutic effect. Results The effective rate of OK-432 group 〔85.7% (36/42)〕 was significantly higher than that of IL-2 group〔63.3%(19/30)〕 (P<0.05). But there was no difference in effective rate between two different year groups (P>0.05). Conclusions The intracavity injection of OK-432 could be effective method for control of malignant pleural effusion, especially in the advanced elderly.