老年急性脑梗死病人脑脊液及血浆中GMP-140、vWF含量的研究

Study of the Contents and Clinical Significance of GMP-140 and vWF in Elder Cerebrospinal Fluid and Plasmain Patients with Cerebral Infarction

目的 研究老年急性脑梗死患者脑脊液(CSF)和血浆中血小板颗粒膜蛋白 14 0 (GMP 14 0 )和血管性假血友病因子(vWF)含量的变化及临床意义。方法 应用双抗夹心酶联免疫吸附试验(ELISA)法测定了34例老年脑梗死急性期病人CSF和血浆中GMP -14 0、vWF的含量。结果 病人组CSF和血浆中GMP 14 0、vWF含量较正常对照组显著升高(P <0. 0 1)。结论 老年急性脑梗死患者存在高凝状态和血小板活化功能亢进以及脑血管内皮的损伤;检测CSF中GMP 14 0和vWF含量的变化对于观察病情演变、判断预后均有一定的临床意义。

Objective To study the contents and clinical significance of Alphagranule membrane protein-140(GMP-140),von Willebrand factor(vWF)in elder cerebrospinal fluid(CSF) and plasma of patients with cerebral infarction.Methods With eLISA method, GMP-140,vWF in CSF and plasma of 34 cases suffering from cerebral infarction were measured and compared. Results During the acute period of cerebral infarction,the contents of GMP-140,vWF in CSF and plasma were higher significantly than that of the control group(P<0.01). Conclusions The GMP-140 and vWF in CSF are the specific parameters of the hypercoagulable state and of the damage at endotheliocyte of cerebral vessels in the elder patients with cerebral infarction.The measurement may be useful for therapy and prognosis of patients with ischemic cerebrovascular diseases.