核素胃食道返流显像在慢性支气管炎和支气管哮喘中的应用

Application of radionclide gastroesophageal re-flux imaging in patieuts with chronic bronchitis andasthma.

为探讨慢性支气管炎（慢支）、支气管哮喘（哮喘）与胃食道返流（ＧＥＲ）的关系，采用放射性核素显像对２９例慢支、３２例哮喘患者及９例正常对照者进行研究。结果：慢支组和哮喘组并ＧＥＲ的发生率分别为５１．７４％和３７．５％，而对照组未发现ＧＥＲ；胃食道核素显像诊断ＧＥＲ的敏感性和特异性分别为１００％和６８．４２％；慢支、哮喘并ＧＥＲ者与其无ＧＥＲ者之间肺通气功能值差异无显著性（Ｐ＞０．０５）；肺核素显像未发现肺吸入返流物现象。提示：慢支和哮喘患者有较高的ＧＥＲ发生率，从而推测慢支、哮喘与ＧＥＲ之间有密切的关系。

o determine the relationship between gastroe-sophageal reflux(GER)and pulmonary diseases,westudied 29 chronic bronchitis,32 asthmatic patients,and 9 control subjects.GER was diagnosed byesophageal endoscopy and gastroesophageal scintiscan-ning.Evidence of GER in the chronic bronchitic pa-tients was 51. 74%;in the asthmatics it was 37.5%;and no GER was confirmed in the control suUects.Gastroesophageal scintiscan had 100%sensitivity, butonly 68. 42%specificity. The mechanism whereby re-flux triggers pulmonary problems was investigated byusing the scintiscan for pulmonary aspiration,but noulmonary aspiration was detected in all suUects. Pul-monary function tests did not show any differences be-tween patients with or without reflux(P>0.05).Thus,our results show that GER is common in chron-ic bronchitics and asthmatics,Which indicates thatthere is some relationship between GER and chronicbronchitis as well as asthma.