强直性脊柱炎活动期临床实验室及影像学诊断研究

Diagnostic Investigation of Clinical laboratory and Imagiology of Ankylosing Spondylitis Active Stage

目的：通过对强直性脊柱炎（AS）的临床、实验室及影像学分析，着重对本病活动期诊断依据进行研究。材料和方法：对110例AS进行临床、实验室及腰椎、骶髂关节平片和CT扫描，并对其中24例进行骨与软组织陵素比值测定。采用量化打分、敏感性试验及Spearman等级相关分析。结果：AS活动期临床主要为下背疼痛、僵硬及睡眠障碍加重；实验室检查ESR、CRP升高和HLA—B27阳性；影像学主要表现骶髂关节侵蚀、硬化分数升高和骨与软组织核素比值升高。结论：上述临床、实验室和影像学指标可作为AS活动期的诊断标准和依据。

Purpose: To analyse the manifestations of clinical, laboratory and imagiology with ankylosingspondylitis (AS) so that investigated the diagnosis standard of active stage. Materials and methods: 110 patientshad examination of clinical and laboratory and plain x-ray films of the lumbar spine and the SI joints and CT scansof the SI joints. 24 cases quantitative sacroiliac and lumbar spine and hip joints radio-isotope (TC- 99m MDP)scans and bone to soft tissue (ST) ratios were per formed. They were completed that scoring and longitudnal sensitive test and and Spearman's rank correlation analysis. Results:on clinic,low back pain and stillness and sleep dis-turbance were more Serious. on laboratory,furthermore,ESR and CRP were raise and HLA-B27 (+ ). on imagiologic,scoring of erosions and sclerosis and bones to soft tissue(ST) ratios showe a increase. Conclusion:Abovementioned sensitive target were regard as a diagnostic standard of AS active stage.