利多卡因预防肿瘤化疗期间恶心呕吐的临床观察

Clinical Observation of Lidocaine in Preventing Nausea and Vomit during Chemotherapy

目的 寻找一种预防肿瘤化疗期间恶心呕吐的有效方法；方法 将１９０ 例病人分为３ 组进行对比观察，一组应用利多卡因；另一组应用利多卡因和胃复安，对照组单纯应用胃复安；结果 利多卡因１００ｍｇ 静脉点滴对预防肿瘤化疗期间引起的恶心呕吐有显著疗效（ Ｐ＜ ０．０１），且无明显副作用；结论 病人在化疗期间应用利多卡因，同时在用药期间加强病人心理护理，做好饮食指导，观察用药后的反应，对提高病人生活质量和预后有良好的效果。

Objective To seek for an effective method to prevent nausea and vomit during chemotherapy. Methods One hundred and ninty patients were divided into 3 groups and contrast observation was made.Lidocaine was used in one group; Lidocaine and Metoclopramid in another group;Metoclopramid in the control group.Results Lidocaine had obvious effect on preventing nausea and vomit.Conclusion Lidocaine is used during chemotherapy, at the same time,mental nursing,diet direction and adverse effect observion are helpful to enhance life quality and prognosis.