急性驰缓性麻痹病原学监测分析

Pathogenological Surveillance of Acute Flaccid Paralysis(AFP)

目的 探讨急性驰缓性麻痹（ＡＦＰ） 病原学变异情况，以便采取相应对策；方法 采用ＰＣＲ—ＲＦＬＰ 法做型内差异分析；结果 １９９５～１９９７ 年ＡＦＰ病例双份合格粪便标本采集率分别为７８ ．９０ ％ 、８０．００ ％ 、７５．７６％ ， 从ＡＦＰ病例及接触者标本中未分离出脊髓灰质炎（ 脊灰） 野病毒，而分离出脊灰疫苗病毒和ＣＯＸ、ＥＣＨＯ 等其它肠道病毒，１９９５ ～１９９７ 年ＡＦＰ标本脊灰疫苗病毒阳性率分别为０．３５％ ，ＡＦＰ标本其它肠道病毒阳性率分别为２６．６７ ％ 、１７ ．８６％ 、３１．２５％ ；结论 引起ＡＦＰ的原因有多种，仍应加强ＡＦＰ监测和诊断。

Objective To explore the pathogenologicalvariation and measurs of acute flaccid paralysis (AFP).Methods PCR-AFLP method was used to make difference analysis among types. Results The collected rate of AFP qualified pairerd fecal specimens was 78.90% in 1995 and 80.00% in 1996 and 75.76% in 1997 respectively.No wild—Type polio virus was isolated from the fecal specimens of AFP and contacts, but polio vaccine virus and Cox. ECHO and other enteroviruses were isolated.The positive isolation rate of polio vaccine virus of AFP specimens was in 1995 and 3.57% in 1996 and in1997, the positive isolation rate of other enterovirus of AFP specimens was 26.07% in 1995 and 17.86% in 1996 and 31.25% in 1997.Conclusion The reasons of AFP lie in many diseases. The surveillance and diannosis of AFP shoud still be strengthened.