甘露醇治疗急性脑血管病引起肾功能损害相关因素分析

Correlative Factors Causing Renal Function Injury in Patients with Acute Cerebral Vascular Disease Treated by Mannitol

目的 探讨甘露醇治疗急性脑血管病引起肾功能损害的危险因素。方法 对符合研究条件的４９０例急性脑血管病患者按合并症分为糖尿病组、高血压病组、冠心病组、混合组及无合并症，对各组患者进行尿蛋白、血清ＢＵＮ、Ｃｒ 动态监测。结果 糖尿病组、高血压病组及混合组并发肾功能损害的发病率高于无合并症组（ Ｐ＜０ ．０５ 或０ ．０１） ，发生肾功能损害的时间包括冠心病组在内均较无合并组提前（ Ｐ＜ ０ ．０１） 。结论 糖尿病、高血压和冠心病可加重甘露醇对肾脏的损害，此时应减少甘露醇用量，缩短应用时间。

Objective To study the correlative factors causing renal function injury in patients with acute cerebral vascular disease treated with mannitol.Methods 490 patients who corresponded with the study were selected.According to their complications, these patients were divided into 5 groups:diabetes mellitus group, hypertension group,coronary heart disease group ,mixture group and group without complication. The urine protein , serum BUN, Cr were dynamically measured in these patients.Results The occurrence rate of complicating renal function injury in diabetes mellitus group, hypertension group and mixture group was higher than that of the group without complication (P<0.05 or <0.01 ). The time that the patients occurred renal function injury in all the complication groups was advanced than that of the group without complication ( P< 0.01 ).Conclusion The diabetes mellitus, hypertension and coronary heart disease may strengthen the damage of mannitol to renal. Under this circumstance, we should reduce the usage of mannitol and shorten the using duration.