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单亲遗传与遗传病 被引量:1

Uniparental Disomy and Genetic Diseases
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摘要 单亲遗传是一种普遍现象,在无性生殖到有性生殖的漫长过程中,其在物种的多样性中起着重要作用。通过对孟德尔在线数据库中有关单亲遗传病的相关资料进行分析,试图探讨基因突变与基因重组在单亲遗传病发病中的作用,阐明印迹调控在单亲遗传病发生中的意义,并进一步深入了解单亲遗传在生殖、发育、肿瘤发病机制和人类老化诸方面的意义。 Uniparental disomy occurs commonly during the long process from the parthenogenetic to sexual reproduction. In the present study, we analyzed the subset of uniparental genetic diseases from the data of the Online Mendelian Inheritance in Man (OMIM). These data illustrated the significance of imprinting in uniparental genetic diseases. We further discussed the implications of pathonogenesis in carcinogenesis and aging.
出处 《南华大学学报(医学版)》 2005年第2期160-165,共6页 Journal of Nanhua University(Medical Edition)
基金 湖南省自然科学基金资助 (0 3JJY40 41) 教育部重点项目 (教技司【2 0 0 5】3号 NO :2 0 5 10 6)
关键词 单亲遗传病 单亲生殖 印迹调控 uniparental genetic diseases parthenogenetic imprinting
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参考文献12

  • 1李凯,张佳,廖端芳,陈琳玲.核化线粒体组学与转基因人分析法[J].中国动脉硬化杂志,2003,11(7):601-602. 被引量:3
  • 2李凯,廖端芳,张佳,陈琳玲,彭翠英,王春.核化线粒体的进化加速作用与转基因人模型分析[J].南华大学学报(医学版),2004,32(1):1-3. 被引量:4
  • 3Cowan DP, Stahlhut JK. Functionally reproductive diploid and haploid males in an inbreeding hymenopteran with complementary sex determination[J].Proceedings of the National Academy of Sciences of the United States of America,2004, 101(28):10374-10379.
  • 4www.encyclopedia.com: In 1900, Jacques Loeb accomplished the first clear case of artificial parthenogenesis when he pricked unfertilized frog eggs with a needle and found that in some cases normal embryonic development ensued. Artificial parthenogenesis has since been achieved in almost all major groups of animals, although it usually results in incomplete and abnormal development. ......, In 1936, Gregory Pincus induced parthenogenesis in mammalian (rabbit) eggs by temperature change and chemical agents.
  • 5Obata Y, Kono T, Hatada I. Maturation of mouse fetal germ cells in vitro[J]. Nature, 2002, 418: 497.
  • 6Kono T, Y Obata, Q Wu,et al. Birth of parthenogenetic mice that can develop to adulthood[J]. Nature, 2004, 428: 860-864.
  • 7Chang MC. Experimental studies of mammalian fertilization[J]. J Exp Zool,1952, 121:351-381.
  • 8Hill KA, Buettner VL, Halangoda A, et al. Spontaneous mutation in Big Blue mice from fetus to old age: tissue-specific time courses of mutation frequency but similar mutation types[J]. Environ Mol Mutagen,2004, 43:110-120.
  • 9Plachot M, Mandelbaum J, de Grouchy J. In vitro parthenogenesis in the human species[J]. Ann Genet,1984, 27: 158-161.
  • 10Strain L, Warner JP, Johnston T, et al. A humna parthenogenetic chimaera[J]. Nat Genet,1995, 11: 164-169.

二级参考文献7

  • 1Valentine JW, Joblonski D, Erwin DH. Fossils, molecules and embryos: new perspectives on the Cambrian explosion[J]. Development,1999, 126: 851-859.
  • 2Bromham L, Penny D. The modern molecular clock[J]. Nature Rev Genetics,2003,4:216-224.
  • 3Krings M, Stone A, Schmitz RW, et al.Neandertal DNA sequences and the origin of modern humans[J]. Cell,1997, 90: 19-30.
  • 4Cann RL, Stoneking M, Wilson AC. Mitochondrial DNA and human evolution[J]. Nature,1987, 325: 31-36.
  • 5Zhang J,Li K.An assembled old version of human mtDNA using nuclear pseudogenes.genbank accession #BN000436.
  • 6Navarro A, Barton NH. Chromosomal speciation and molecular divergence-accelerated evolution in rearranged chromosomes[J]. Science,2003, 300: 321-324.
  • 7李凯,廖端芳,张佳,陈琳玲,彭翠英,王春.核化线粒体的进化加速作用与转基因人模型分析[J].南华大学学报(医学版),2004,32(1):1-3. 被引量:4

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