肠内免疫微生态营养支持对重症急性胰腺炎犬肝损害的影响

The effect of enteral ecoimmunonutrition supports on hepatic injury in severe acute pancreatitis.

目的探讨不同营养支持对重症急性胰腺炎(SAP)肝损害的影响。方法犬重症急性胰腺炎模型诱导后,随机分为3组,分别行肠内要素营养(EEN组)、肠内免疫微生态营养(EIN组)和肠外营养(PN组)支持7d。检测其肝功能变化及肝脏组织病理改变。结果与重症急性胰腺炎诱导前相比,诱导后ALT、AST水平显著升高,ALB显著降低,差别具有显著性(P<0.05)。EIN组肝功能指标均较EEN组及PN组改善,具有显着性差异(P<0.05),肝脏病理学改变PN组最重,EIN组最轻。结论早期肠内免疫微生态营养,补充肠道正常菌群,减少细菌易位,可减轻急性胰腺炎时的肝损害。

Objective To explore the role of different nutritional supports on hepatic injury in severe acute pancreatitis (SAP). Methods After induction of the dog pancreatitis model, the animals were divided into 3 groups randomly, which were supported with enteral elementary nutrition(EN), enteral ecoimmunonutrition(EIN) and parental nutrition(PN) for 7 days respectively. Hepatic function and histo pathology of the dogs were evaluated. Results ALT and AST levels in SAP group were significantly high as compared with those before SAP induction (P< 0. 05), and ALB level was significantly low(P < 0. 05). The difference in hepatic injury was significant between EEN, EIN and PN groups (P < 0. 05). Hepatic injury was the most severe in PN group and mildest in EIN group. Conclusions EIN can compensate for normal flora in the gut, reduce bacterial translocation, modulate immunologic function, alleviate hepatic injury in SAP.