骨密度随龄变化特点及某些相关因素分析

An analysis of the characteristics of bone mineral density changes with aging and some other related factors

报道了２６６名汉族健康人腰椎、股骨上端骨密度（ＢＭＤ）的随龄变化及其与性别、年龄、体重的关系以及８０岁以上老年人血生化、性激素与ＢＭＤ的关系。结果表明：男性随增龄股骨颈、股骨三角（Ｗａｒｄ三角）及股骨粗隆ＢＭＤ逐渐减低，腰椎（Ｌ２～Ｌ４）ＢＭＤ变化不明显；而女性Ｌ２～Ｌ４、股骨颈、Ｗａｒｄ三角、股骨粗隆的ＢＭＤ随增龄均逐渐减低。全部受检者不分性别，其ＢＭＤ丢失速度：Ｗａｒｄ三角＞股骨粗隆＞股骨颈＞Ｌ２～Ｌ４。各测定部位间ＢＭＤ相关良好，ＢＭＤ与年龄呈负相关，与体重呈正相关。８０岁以上老年人ＢＭＤ与血清睾酮水平呈正相关，与血清磷和碱性磷酸酶呈负相关，与血清钙和雌二醇呈弱的正相关。

Abstract Bone mineral density(BMD) changes of the lumbar vertebral and the upper part of femur in 266 normal subjects of Han nationality in relation to aging process were reported. The relationship between the BMD changes and some palameters such as sex,age,body weight,blood biochemistry and sex hormone level was studied.It is shown that in male subjects BMD of the femoral neck,triangle(ward's triangle) and trochanters decreased with aging,but that of 2nd to 4th lumbar vertebral did not.On the contrary,in female subjects BMD decreased not only in different parts of femur,but also in tbe lumbar ventebral.In both sexes the speed of BMD changes in different parts of the bones was in such an order:Ward's tringle>trochanters>neck>lumbar vertebral.The relation between BMD changes and aging was obvious.BMD was correlated negatively with aging and positively with body weight.In subjects aged over 80,BMD was correlated positively with the blood level of testosterone and hegatively with that of phosphorus and alkaline phosphatase,but it was only weakly correlated with the blood level of calcium and estradiol.