脊髓灰质炎中和抗体母婴垂直分布血清流行病学研究

A Longitudinal Study on Maternal-fetal Transfer of Antihody against Poliomyelitis

本文对孕妇血、新生儿脐血和２月龄婴儿血中脊灰三型中和杭体垂直分布情况进行研究。结果表明：孕妇血中脊灰三型抗体阳性率在９２．５％以上；ＧＭＴ在１４．５８～３２．６７之间；Ⅰ、Ⅱ型阳性率、ＧＭＴ基本一致，Ⅲ型较低，新生儿脐血比该孕妇血中ＧＭＴ低５０％左右，２月龄婴儿血脊灰三型抗体阳性率和ＧＭＴ均低于母血和新生儿脐血中脊灰抗体阳性率和ＧＭＴ；２月龄婴儿脊灰单型抗体阴转率达６４．１％～８３．８７％，三个型别抗体均阴转者达４４．８％，与生母及新生儿脐血中和抗体水平呈明显负相关，表明婴儿出生后至２个月初次免疫前，确实存在着免疫裂隙，建议推行新生儿“０”次接种或孕妇第２８周开始服ＯＰＶ。

study on antibody distribution and titer aga-inst poliovirus in 67 mothers and their 60-day-old new-born babies was carried out in Shi-yan, Hubei Province. The positive rates andthe geometric mean titers of antibodies aga-inst Types Ⅰ-Ⅲ poliovirus in mnothers were98.58%,1 : 32.67; 95.5%,1: 30.07; 92.5%,1:14.58,respectively.In their 60-day-old babies,theantibody positive rates and geometric meantiters fell obvionsly; they were 34.3%,1:2.45:34.3%,1:2.22; and 14.9%,1:1.34, respectiv-ely. The authors suggest to immune those neo-nates(OPV zero),or to immune those moth-ers beginning from 28 weeks of pregnancy inorder to raise the antibody titer and protecttheir babies during the early days.