微导管脑动脉超选灌注BCNU与ACNU治疗脑恶性肿瘤临床研究

The clinical study of microcatheter superselective intracerebral arterial infusing BCNU and ACNU to treat brain Malignant tumor

目的：本文报告了28例脑恶性肿瘤应用不同化学药物和方法．延长病人生存期．改善生存质量以及并发症防治。材料与方法：将28例脑恶性肿瘤病人随机分二组，施行微导管脑动脉超选灌注化学药物BCNU与ACNU．每次剂量分别为100～200mg／m2和2～3mg／kg。结果：近期疗效，应用BCNU组有效率85．1％；应用ACNU组有效率100％。三年生存率：BCNU组42．8％；ACNU组64．3％，并发症；ACNU组明显低于BCNU组。结论；采用微导管脑动脉超选灌注化学药物治疗脑恶性肿瘤方法，疗效优于静脉及其它给药方法。药物ACNU疗效高于BCNU，并且药物ACNU的毒副作用小并发症少。

Purpose: Chemotherapeutics is recognized a effective methods to control the brain rnallgnant tumors. It can prolong the patients living period and provc patients living quality. 28 cases of cerebral malignant tumor patients who received intracerebral arterial infusion chemother apy are reported in this study. Method: 28 cases of cerebral malignant tumor patients who treated by rnlcrocatheter superselective intracerebral arterial infusing BCNU and ACNU are randomizing into two groups. Dose of infusion one time of BCNU was 100 - 200mg/m2 and ACNU was 2 3mg/kg. Results: Recent effects in BCNU is 85.1% and ACNU is 100% . 3 year living rate of BCNU is 42. 8% and ACNU is 64. 3% . The complications of group ACNU is lower than group BCNU. Conclusion: The method of microcatheter superselective intracerebral arterial drugs infusion to treat cerebral malignant tumor is much more effective than venous chemotherapeutics and other methods. The effective of BCNU is much lower than ACNU. But the toxity and complication of BCNU is higher Than ACNU.