MPTP对小鼠纹状体多巴胺含量的影响

The effect of MPTP on striatal dopamine in C57BL mice

用高效液相色谱法检测Ｃ５７ＢＬ型老龄及幼龄鼠注射１－甲基－４－苯基－１，２，３，６四氢吡啶（ＭＰＴＰ）两周及两个月后纹状体多巴胺含量，发现幼龄鼠两个月后多巴胺由两周时的１．９±０．４μｇ／ｇ（比对照组减少８２％）升高至５．１±０．５μｇ／ｇ（比对照组减少５２％）；而老龄鼠则无明显改变。这说明老龄鼠多巴胺神经元损害修复的功能减退，这可能是帕金森病多发于老年人的原因之一。

Abstract The levels of striatal dopamine in mice two weeks and two months after MPTP treatment by high performance liquid chromatography with electrochemical detection were measured. The results showed that the dopamine in young mice rose from 1.9±0.4μg/g (82% depletion compared to control) 2 week after MPTP to 5.1±0.5μg/g (52% depletion compared to control) 2 months later, but no significant changes were found in aged mice. This suggested that the capacity of aged dopaminergic neuron to recover from insults decreased.This may be one of the reasons that Parkinson's disease occurred more frequently in old people.