摘要
用高效液相色谱法检测C57BL型老龄及幼龄鼠注射1-甲基-4-苯基-1,2,3,6四氢吡啶(MPTP)两周及两个月后纹状体多巴胺含量,发现幼龄鼠两个月后多巴胺由两周时的1.9±0.4μg/g(比对照组减少82%)升高至5.1±0.5μg/g(比对照组减少52%);而老龄鼠则无明显改变。这说明老龄鼠多巴胺神经元损害修复的功能减退,这可能是帕金森病多发于老年人的原因之一。
Abstract The levels of striatal dopamine in mice two weeks and two months after MPTP treatment by high performance liquid chromatography with electrochemical detection were measured. The results showed that the dopamine in young mice rose from 1.9±0.4μg/g (82% depletion compared to control) 2 week after MPTP to 5.1±0.5μg/g (52% depletion compared to control) 2 months later, but no significant changes were found in aged mice. This suggested that the capacity of aged dopaminergic neuron to recover from insults decreased.This may be one of the reasons that Parkinson's disease occurred more frequently in old people.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
1994年第1期6-7,共2页
Chinese Journal of Geriatrics