老年人十二指肠溃疡胃年龄代的研究

A study on chronological stomach age in aged patients with duodenal ulcer

研究胃底腺区与幽门腺区腺境界的改变。分三组：老年人十二指肠溃疡（溃疡组）和老年人慢性胃炎（胃炎组）各２０例，青年人非溃疡性消化不良（对照组）５例。用刚果红染色后注射五肽胃泌素，并对胃各部位进行活检。结果显示：溃疡组的腺境界几乎不上移，发生萎缩性胃炎少而轻，属中度萎缩者占２５％，无重度萎缩；而胃炎组几乎全部（１９例）有慢性萎缩性胃炎，属中度和重度萎缩者分别占２５％和５０％。两组比较，差异有极显著性（Ｐ＜０．００１），证实溃疡组与对照组的腺境界相似。说明老年人患十二指肠溃疡者具年轻人的胃年龄代。

Abstract The gland border between fundal and pyloric gland areas was studied by Congo-red stain followed by pentagastrin injection, and then biopsy on gastric mucosa under endoscopy in 4o patients. The patients were divided into three groups: 20 aged with duodenal ulcer (ADU group), 20 aged with chronic gastritis (ACG group)and 5 young patients with non-ulcer dyspepsia as control group. In ADU group, there were only 5 cases (25%) with moderate gastric atrophy (C3,01), no severe atrophy was found. While in the ACG group, 19 cases had various degrees of atrophy. Among them there were 15 cases with moderate and severe atrophy (02,03) that were 25% and 50% separately. In contrast, none in the young group showd atrophy. The difference between the ADU and ACG group was very significant (P<0.001). The results indicate thnt most of ADU kept normal foundal gland area, similar to tbe young control group. It implies that the ADU patients may have normal gland border and younger chronological stomach age.