老年肺部感染患者白细胞介素2活性的变化

A study on interleukin-2 activity in the aged patients with lung infection

对５０例老年肺部感染患者白细胞介素２（ＩＬ－２）的活性进行了测定。结果表明：老年肺部感染患者ＩＬ－２活性（４．１±４．０Ｕ／ｍｌ）显著低于健康老年人（１３．０±１０．１Ｕ／ｍｌ）（Ｐ＜０．００１），亦明显低于非老年肺部感染患者（７．２±５．４Ｕ／ｍｌ）（Ｐ＜０．０５）。肺部急性感染患者当感染控制后ＩＬ－２活性显著回升（１１．１±７．５Ｕ／ｍｌ）（Ｐ＜０．００１）。此外，病程＞４年的老年肺结核患者ＩＬ－２活性（２．８±２．０Ｕ／ｍｌ）低于病程＜４年的患者（７．７±５．７Ｕ／ｍｌ）（Ｐ＜０．０５）；重症患者（２．９±２．８Ｕ／ｍｌ）低于轻症患者（８．５±５．４Ｕ／ｍｌ）（Ｐ＜０．０１）。提示肺部感染及肺结核的严重程度和病程均可影响老年患者的ＩＬ－２活性。ＩＬ－２可反映老年肺部感染患者的免疫状态。

Abstract Interleukin-2 (IL-2)activity was determined in 50 aged patients with lung infection.The IL-2 activity in aged patients with lung infection (4.1±4.OU/ml) was significantly lower than that in the healthy control (13.0±10.1U/ml)(P<0.001),and also significantly lower than that in the non-aged patients with lung infection (7.2±5.4U/ml)(p<0.05).When acute lung infection was brought under control,IL-2 activity rose significantly(11.1±7.5U/ml)(p<0.001).IL-2 activity in aged patients with pulmonary tuberculosis whose history was over 4 years(2.8±2.OU/ml) was lower than that in those patients whose history was within 4 years(7.7±5.7U/ml)(P<0.05).IL-2 activity in the severe patients (2.9±2.8U/ml) was significantly lower than that in the mild patients (8.5±5.4U/ml)(P<0.01).These data suggest that the IL-2activity in the aged can be affected by lung infection.IL-2 activity reflects the immune function of aged patients with lung infection.