硫酸镁对大鼠颅脑损伤后内皮素一氧化氮的影响

Effect of Magnesium Sulphate on Errdothelion' Nitric Oxide of Posttraumatic Rats

目的 观察硫酸镁对大鼠颅脑损伤后血脑组织中ET、NO含量的影响 ,并探讨其作用机制。方法 将SD大鼠随机分为正常对照组损伤组和治疗组 ,治疗组在致伤后腹腔注射硫酸镁 ,伤后 6小时测定血脑组织中的ET、NO含量 ,脑组织病理学检查 ,并进行比较分析。结果 颅脑损伤后血NO减少 ,ET增多 ;脑组织中NO、ET均增加。应用硫酸镁治疗可使上述改变程度减轻 ,脑水肿减轻。结论 颅脑损伤后脑组织ET、NO含量增加 ,参与了继发脑损伤的病理过程。早期应用硫酸镁治疗 ,通过对ET、NO水平的影响 ,减轻继发性脑损伤 。

Objective To explore the effect of magnesium sulphate on the level of ET, NO in rat blood, brain and the mechanism. Methods SD rats were divided into the control traumatic and the therapeutic group randomly.In the therapeutic group magnesium sulphate were injected into the abdomem of posttraumatic rats, then the blood and brain level of ET, NO were detected after six hours, the data were compared with the control group. Results The posttaumatic blood level of ET was decreased but NO was increased. Yet the brain ET, NO levels were increased, the treatment with magnesium sulphate could reduce the rariution. Conclusion The increasing of ET and NO after craniacerebral injury interferes into the pathophsiological process of second injury. But the early treatment with magnesium can relieve the secondary injury through the effect on the levels of ET and NO.