氟桂利嗪、顺铂对食管癌放射增敏作用的临床研究

Clinical Research on Radiopotentiation of Cinnarizine and Cisplatin in Treating Esophagus

目的 氟桂利嗪、顺铂与放射联合应用治疗食管癌 ,以观察氟桂利嗪、顺铂是否有放射增敏作用。方法 治疗组 :口服氟桂利嗪、静脉点滴顺铂、60 Co照射。对照组 :照射方法和技术同治疗组 ,不加用氟桂利嗪和顺铂。观察两组放射治疗结束时、放射治疗结束后 1个月、6个月的食管X线片变化 ,并观察放疗及氟桂利嗪、顺铂的急性毒副作用。结果 治疗组放疗组放射结束时、放射治疗结束后 1个月、6个月的食管X线片 1、2级分别为 4 8.0 %、5 4 .7%、5 0 .6 % ,而对照组同期食管X线片 1、2级分别为 2 6 .0 %、32 .0 %、2 8.0 % ,治疗组近期疗效显著优于对照组 (P <0 .0 5 )。但治疗组血液系统毒性、胃肠反应发生率与对照组比较有非常显著差异 (P <0 .0 0 1)。结论 氟桂利嗪、顺铂对食管癌的放射治疗有增敏作用 ,但有一定毒性 。

Objective To investigate whether there is radiopotentiation when cinnarizine and cisplatin (DDP) combined radiopraxis to treat esophagus cancer. Methods The treatment group was given cinnarizine orally and intravenous drip of cisplatin (DDP) on the basis of radioprasis. The control group was also given the same radiopraxis method and technique without cinnarizine and DDP. The changing of esophogus X-ray was studied when radiopraxis finished, one month and 6 months after the procedure,observe the acute toxic side effect.Results The rate of I～II grade of esophagus-X ray was 48%,54.7%,50.6% respectively ot finishing time one week later and 6 months later. While in the control group, the rate was 26%, 32%,28% respectively. The treating group had an obervious effect compared with the control group (P<0.05), but in the treatment group, blood toxis, intestin reaction rate was significantly different from the control group (P <0.0001).Conclusion DDP and cinnarizine have radiopotentiation in treating esophagus cancer,but have toxis and should be improved.