PCNA和RAR-α在肝细胞癌中的表达

Expression of PCAN and RAR-α in hepatocellular carcinoma

目的 比较PCNA和RAR -α染色对HCC增殖的评估和相互关系。方法 对 4 4例肝细胞癌病例的石蜡切片 ,用免疫组化染色法 ,分别行增殖核抗原和维甲酸α核受体染色 ,比较两者对HCC增殖的评估和相互关系。结果 PCNA在HCCs中的阳性率为 34.8% ,RAR -α在HCCs中的阳性率为 36 .4 % ;HCC分化越差 ,PCNA和RAR -α阳性率越高 ,同时 ,我们证实PCNA和RAR -α在原发性肝细胞癌中的阳性率有十分密切的正相关关系。结论 RAR

Objective A study of relationship between the expression of proliferating cell nuclear antigen and retinoic acid receptor α in hepatocellular carcinoma .Methods Forty-four cases of HCCs were studied immunohistochemically by using monoclonal antibodies PCNA and RAR-α.Results We studied correlation between PCNA and RAR-α in HCCs and evaluated of the proliferation of HCCs.PCNA positive rate of HCCs was 34.8%,RAR-α positive rate of HCCs was 36.4%.The lower the differentiation of HCCs,the higher the RAR-α and PCNA positive rate.We also demonstrated a direct correlation between RAR-α staining and PCNA staining in HCCs(r=0.88,P>0.05)RAR-α and PCNA expression levels might be of practical use on the evaluation of proliferation of HCCs.Concluion RAR-α and PCNA can evaculate the proliferating of HCC.