丙型肝炎病毒家庭内感染状况的血清学调查

Serological Investigation on intra-familial Transmission of HCV Infection

对６０例抗－ＨＣＶ阳性患者的家庭成员１２４人进行血清学检测，并收集４０例乙肝患者的家庭成员８３人为对照．结果丙肝组检出抗－ＨＣＶ阳性的家庭成员９人，检出率７．３％．除去有供血史的抗－ＨＣＶ阳性家庭成员，检出率为１．８５％（２／１０８）．乙肝组未检出抗－ＨＣＶ阳性者．在单一丙肝家庭组中，家庭成员的ＨＢＶ感染率为２５．３３％，而在ＨＢＶ／ＨＣＶ重叠感染和ＨＢＶ感染组的家庭成员中，ＨＢＶ的感染率为４０．９１％，故提示，ＨＣＶ的家庭内聚集性感染的危险性远低于ＨＢＶ，且母于垂直传插的危险性更低于夫妻间水平传播．

To clarify the intrafamilial trasmission ofHCV infection,the antibody to HCV wasassayed in 124 serum samples from the familymembers of 60 HCV-Ab(+)index cases(groupc),and compared with that from 83 familymembers of 40 HCy-Ab(-)index patientswith hepatitis B(group B). Nine of 124,including 2 parents, 6 spouse and 1 grand-danghter, were positive for anti-HCV.Theprevalence of anti-HCV was 7.3%(9/124)intotal, and 1.85%(2/108)in the subjects who hadno history of blood donation. None of 83 waspositive for anti-HCV in group B.On the otherhand,the praralence of HBV infection was25. 33%in the group of HCV infection only, and40.91% in the group with HBV/HCV double-infection or HBV infection,It indicates thatthe risk of HBV intrafamilial trasmission ishigher than that of HCV,and the risk oftrasmission of HCV from mather to infant maybe lower than that of sexual trasmission.