医院工作人员HBV－M的调查和接种乙肝疫苗的观察

Investigation on HBV-Mamong HospitalWorkers and Observation on the Efficacyof Vaccination against Type B Hepatitis

对我院院龄１～４年的３１５名工作人员进行ＨＢＶ－Ｍ调查中，发现显性乙肝患者１２例（３．８％）、隐性乙肝感染者１２６例（４０％），共１３８例（４３．８％）。其中ＨＢｓＡｇ阳性２０例（６．３％）、抗－ＨＢｃ阳性２７例（８．６％）、抗－ＨＢｓ阳性９１例（２８．９％）。提示乙肝对医务人员健康有严重的威胁；但手术科室与非手术科室、血库、检验人员与其他科室人员的感染率无明显差异。对ＨＢＶ－Ｍ均阴性的１７７例进行了血源性乙肝疫苗接种，注射第三针后，抗－ＨＢｓ阳转１５８／１７３例（９１．３％），认为我国血源乙肝疫苗使用安全且有良好的免疫效果。

An epidemiological study on HBV infection among 315 staff of PUMC Hospital was carried out with detection of HBsAg,anti-HBs and anti-HBc by ELISA.The resulls showed that 138 persons had one or more markers of HBV infection and an overall HBV prevalence rate 43.8%.The positive rates of HBsAg anti-HBs,anti-HBc uere 6.3%,28.9% and 8.6%,respecti- vely.This indicates that HBV infection is a risk factor for medical staff,but there was no significant difference among medical,surgical and other members.In 1992,177 workers whose HBV markers were negative received 3 doses of HB vaccine at 0,1 and 6 months,resnpectively.91.3percent of them showed an anti-HBs response one month after the last inoculation.The result shows that our national made HB vaccine is safe and immunogenic.