肝炎病毒重叠感染

Superinfection of Hepatitis Viruses

１８５例ＨＢＶ感染者，用ＥＬＩＳＡ法检测抗－ＨＡＶ－ＩｇＭ和抗－ＨＣＶ。ＨＢＶ感染者的ＨＡＶ、ＨＢＶ二重感染率为１７．３０％，ＨＢＶ、ＨＣＶ二重感染率为３．２４％，ＨＡＶ、ＨＢＶ、ＨＣＶ三重感染率为０．５４％。３２例ＨＡＶ和ＨＢＶ二重感染者，ＨＢｅＡｇ２８例转阴；与１５３例单纯ＨＢＶ感染者５７例转阴比较，有显著性差异（Ｆ＜０．０５），３２例甲、乙型肝炎二重感染者，肝功复常天数（３０．３±１２．１）与２３０例单纯甲型肝炎复常天数（２５．５±１３．５）比较，也有显著性差异。ＨＢＶ和ＨＣＶ二重感染以及ＨＡＶ、ＨＢＶ、ＨＣＶ三重感染者，也使ＨＢｅＡｇ转阴，病情重、病程长。这些结果提示，甲、乙、丙型肝炎重叠感染比单一感染者的预后差，不少甲型肝炎慢性化可能是重叠感染乙型肝炎或／及丙型肝炎的缘故。

sing ELISA method,anit-HAV-IgM andanti-HCV were determined in 493 blood donorsand 192 patients with HBV infection.The posi-tive rate of anti-HCV in blood donors was1.62%.The superinfection rates of HBV andHAV,HBV and HCV,HBV,HAV and HCV in patients with HBV infection were16.7 %,3.13% and 0.52%, respectively.Theincidence of hepatitis B viral replicationmarker was found to be lower in patients withsuperinfection of types A and B and/or C hepa-titis viruses than in those with HBV infectionalone.The prolonged course was found to belonger and the degree severer in patients withsuperinfection of types A and B and/or Chapatitis viruses than in those with HAV orHBV or HCV infection alone.The resultssuggest that those patients with superinfectionof types A and B and/or C hepatitis virusesshowed poor prognosis and prolonged course,and many patients with chronic Type A hepati-tis resulted from superinfection HBV and/or HCV.