诱导型一氧化氮合酶在变应性真菌性鼻-鼻窦炎黏膜中的表达

Expression of inducible nitric oxide synthase in allergic fungal rhinosinusitis

目的 :通过对变应性真菌性鼻 鼻窦炎窦腔病变黏膜 (AFRS)和慢性鼻窦炎 (CRS)病变黏膜中诱导型一氧化氮合酶 (iNOS)的定位和半定量研究 ,探讨AFRS和CRS发病机制的差异 ,一氧化氮 (NO)的生成情况和意义。方法 :用免疫组化 (S P法 )的方法对 2 8例AFRS和 6例CRS标本中iNOS进行定位和半定量检测。并且用Ridit分析进行统计分析。结果 :iNOS广泛存在于上皮组织、血管内皮、平滑肌细胞、黏膜下浆液性腺体和炎症细胞中 ,以细颗粒或粗颗粒存在于细胞质中 ,细胞膜上偶见。细胞核及间质细胞内无iNOS表达。AFRS黏膜与CRS黏膜之间的表达差异有显著性意义 (P <0 .0 1)。结论 :iNOS在AFRS窦腔黏膜中呈大量表达 ,iNOS对AFRS发病起重要作用 ;

Objective: To investigate the expression of inducible nitric oxide synthase(iNOS) in the mucus involved in allergic fungal rhinosinusitis(AFRS) and chronic sinusitis(CRS). Method:The iNOS expression was examined using immunohistochemistry in cases of AFRS as well as CRS. Result:The expression rate of iNOS in AFRS was significantly higher than in CRS. Conclusion:The increased expression of iNOS may involve in AFRS pathogenesis. Statistical difference between AFRS and CRS groups may indicate two groups may be distinct diseases entity.