普鲁卡因对中枢作用的实验研究

An experimental study on the central effects of procaine.

用动物实验证实了普鲁卡因的镇痛、镇静和致惊作用。小鼠热板法测得普鲁卡因的镇痛ＥＤ５０为２１．７ｍｇ／ｋｓ（ｉｖ）和５２．８ｕｇ／只（ｉｅｖ）；电刺激法之镇痛ＥＤ５０为２９．２ｍｇ／ｋｇ（ｉｖ）和５２．２ｕｇ／只（ｉｃｖ）。普鲁卡因可增强阈下催眠剂量戊巴比妥钠对小鼠和免的催眠作用，但不能减小小鼠的自主活动。普鲁卡因对兔之惊厥ＥＤ５０分别为１３．５ｍｇ／ｋｇ（ｉｖ）和２．１ｍｇ／只（ｉｅｖ）。单独ｉｖ或ｉｃｙ普鲁卡因不能使全部实验动物翻正反射消失。这些结果显示普鲁卡因的镇痛、镇静作用是较弱的，普鲁卡因只有和其它药物合用．才能产生满意的麻醉效果。

The analgesic, sedative and convulsive effects of procaine were determined by animal experiments. The analgesic ED50 of procain were 21.7mg/kg or 52.8ug/ each (iv or icv, hot plate) and 29.2mg/kg or 52.2ug/ each (iv or icv,electral stimulation) in mice.Procaine In subthreshold dose had additive hypnotic effect of phenobarbital in mice and rabbits, but could not de crease spontaneous activity in mice.The convulsive ED50 of procaine were 13.5mg/kg (iv) or 2.4mg/each (icv) in rabbits.There was no influence on the righting reflex in all the experiment animals when iv or icv procaine was given alone.These results suggest that the analgesic and sedative effects of procaine are weak, but may be potentiated when administered concomitantly With other potent drugs.